Info
| ID | 3397 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 2, "P": 1} |
| Abbreviation | 2 |
| SMILES | COC(=O)c1ccccc1.CP(C)c1ccc2ccc3cccc4ccc1c2c34.[Cl-].[Cl-] |
TUCAN
C26H23O2PRu/(1-25)(2-27)(3-24)(4-28)(5-47)(6-35)(7-34)(8-37)(9-45)(10-45)(11-31)(12-26)(13-30)(14-29)(15-47)(16-47)(17-48)(18-32)(19-48)(20-48)(21-33)(22-36)(23-45)(24-30)(24-39)(25-32)(25-39)(26-27)(26-38)(27-42)(28-29)(28-42)(29-31)(30-41)(31-41)(32-49)(33-35)(33-44)(34-35)(34-37)(36-37)(36-44)(38-43)(38-49)(39-43)(40-41)(40-42)(40-43)(44-46)(45-51)(46-50)(46-51)(47-52)(48-52)(49-52)(51-53)(52-53)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| SW620 | 1.9 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| A375 | 2.2 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| A549 | 5 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| MCF-7 | 5 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
| MCF-10A | 5.5 | — | 10.1021/acs.inorgchem.8b02541 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complexes 1−6 are all capable of inducing apoptosis, but with various degrees of magnitude.»