Info
| ID | 3394 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | K5 |
| SMILES | COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCn1ccnc1.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCn1ccnc1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C62H54Cl2F2N14O4Ru/(1-58)(2-83)(3-89)(4-56)(5-67)(6-55)(7-82)(8-105)(9-59)(10-57)(11-107)(12-61)(13-101)(14-86)(15-87)(16-89)(17-107)(18-70)(19-72)(20-105)(21-62)(22-74)(23-90)(24-77)(25-64)(26-73)(27-63)(28-84)(29-68)(30-65)(31-66)(32-69)(33-90)(34-77)(35-78)(36-108)(37-99)(38-102)(39-105)(40-60)(41-100)(42-88)(43-76)(44-71)(45-106)(46-75)(47-78)(48-108)(49-106)(50-81)(51-85)(52-106)(53-121)(54-122)(55-59)(55-81)(56-59)(56-91)(57-58)(57-92)(58-67)(60-96)(60-115)(61-70)(61-96)(62-79)(62-109)(63-64)(63-68)(64-94)(65-73)(65-95)(66-80)(66-111)(67-82)(68-85)(69-93)(69-110)(70-113)(71-97)(71-116)(72-76)(72-97)(73-74)(74-84)(75-98)(75-112)(76-114)(77-89)(77-107)(78-90)(78-108)(79-93)(79-103)(80-98)(80-104)(81-125)(82-117)(83-86)(83-123)(84-119)(85-126)(86-118)(87-88)(87-124)(88-120)(89-123)(90-124)(91-94)(91-125)(92-95)(92-117)(93-129)(94-126)(95-119)(96-121)(97-122)(98-130)(99-118)(99-123)(100-120)(100-124)(101-127)(101-129)(102-128)(102-130)(103-121)(103-127)(104-122)(104-128)(105-132)(106-134)(107-131)(108-133)(109-110)(109-131)(110-132)(111-112)(111-133)(112-134)(113-115)(113-135)(114-116)(114-136)(115-137)(116-138)(125-139)(126-139)(127-139)(128-139)(129-139)(130-139)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 23 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| A431 | 29 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| MCF-7 | 47 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| HeLa | 50 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Fluorescence-activated cell sorting (FACS) analysis by flow cytometry revealed that complex K4 (Figure 4d) induced mainly late-stage apoptosis and necrosis and showed much more overall cytotoxicity ag...»