Info
| ID | 3393 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | K4 |
| SMILES | COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCn1ccnc1.[Cl-].c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C45H35ClFN9O2Ru/(1-39)(2-40)(3-36)(4-48)(5-42)(6-63)(7-37)(8-59)(9-72)(10-43)(11-60)(12-75)(13-75)(14-73)(15-51)(16-75)(17-62)(18-38)(19-61)(20-64)(21-53)(22-46)(23-45)(24-76)(25-65)(26-41)(27-44)(28-65)(29-52)(30-76)(31-50)(32-47)(33-53)(34-49)(35-82)(36-37)(36-54)(37-59)(38-42)(38-60)(39-40)(39-54)(40-55)(41-43)(41-61)(42-55)(43-56)(44-52)(44-64)(45-50)(45-79)(46-69)(46-80)(47-57)(47-77)(48-49)(48-56)(49-58)(50-69)(51-71)(51-78)(52-58)(53-65)(53-76)(54-66)(55-67)(56-68)(57-71)(57-74)(58-70)(59-84)(60-85)(61-87)(62-63)(62-83)(63-81)(64-88)(65-83)(66-67)(66-84)(67-85)(68-70)(68-87)(69-82)(70-88)(71-89)(72-81)(72-83)(73-86)(73-89)(74-82)(74-86)(75-90)(76-91)(77-78)(77-91)(78-90)(79-80)(79-92)(80-93)(84-94)(85-94)(86-94)(87-94)(88-94)(89-94)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 11 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| A431 | 11 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| MCF-7 | 12 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| A549 | 25 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Fluorescence-activated cell sorting (FACS) analysis by flow cytometry revealed that complex K4 (Figure 4d) induced mainly late-stage apoptosis and necrosis and showed much more overall cytotoxicity ag...»