Info
| ID | 3392 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | K3 |
| SMILES | COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCn1ccnc1.[Cl-].c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C44H33ClFN9O2Ru/(1-36)(2-38)(3-34)(4-45)(5-40)(6-69)(7-35)(8-56)(9-41)(10-57)(11-72)(12-48)(13-72)(14-72)(15-59)(16-37)(17-58)(18-61)(19-73)(20-43)(21-47)(22-73)(23-60)(24-39)(25-42)(26-62)(27-49)(28-50)(29-70)(30-44)(31-62)(32-46)(33-79)(34-35)(34-51)(35-56)(36-38)(36-51)(37-40)(37-57)(38-52)(39-41)(39-58)(40-52)(41-53)(42-49)(42-61)(43-47)(43-76)(44-66)(44-77)(45-46)(45-53)(46-55)(47-66)(48-68)(48-74)(49-55)(50-54)(50-75)(51-63)(52-64)(53-65)(54-68)(54-71)(55-67)(56-81)(57-82)(58-84)(59-60)(59-78)(60-80)(61-85)(62-73)(62-80)(63-64)(63-81)(64-82)(65-67)(65-84)(66-79)(67-85)(68-86)(69-78)(69-80)(70-83)(70-86)(71-79)(71-83)(72-88)(73-87)(74-75)(74-88)(75-87)(76-77)(76-89)(77-90)(81-91)(82-91)(83-91)(84-91)(85-91)(86-91)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A431 | 23 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| MCF-7 | 30 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| A549 | 34 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| HeLa | 42 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Fluorescence-activated cell sorting (FACS) analysis by flow cytometry revealed that complex K4 (Figure 4d) induced mainly late-stage apoptosis and necrosis and showed much more overall cytotoxicity ag...»