Info
| ID | 3391 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | K2 |
| SMILES | COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCn1ccnc1.[Cl-].c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C41H35ClFN9O2Ru/(1-36)(2-39)(3-40)(4-55)(5-42)(6-37)(7-53)(8-56)(9-59)(10-68)(11-38)(12-60)(13-71)(14-71)(15-69)(16-49)(17-71)(18-53)(19-47)(20-58)(21-46)(22-41)(23-57)(24-50)(25-72)(26-52)(27-44)(28-72)(29-51)(30-61)(31-43)(32-45)(33-61)(34-48)(35-78)(36-37)(36-40)(37-55)(38-39)(38-56)(39-42)(40-62)(41-43)(41-46)(42-63)(43-64)(44-45)(44-52)(45-65)(46-59)(47-66)(47-76)(48-54)(48-73)(49-67)(49-74)(50-51)(50-75)(51-66)(52-60)(53-61)(53-72)(54-67)(54-70)(55-80)(56-81)(57-58)(57-79)(58-77)(59-82)(60-84)(61-79)(62-63)(62-80)(63-81)(64-65)(64-82)(65-84)(66-78)(67-85)(68-77)(68-79)(69-83)(69-85)(70-78)(70-83)(71-86)(72-87)(73-74)(73-87)(74-86)(75-76)(75-88)(76-89)(80-90)(81-90)(82-90)(83-90)(84-90)(85-90)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A431 | 18 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| HeLa | 26 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| A549 | 34 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
| MCF-7 | 35 | — | 10.1021/acs.inorgchem.6b00309 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Fluorescence-activated cell sorting (FACS) analysis by flow cytometry revealed that complex K4 (Figure 4d) induced mainly late-stage apoptosis and necrosis and showed much more overall cytotoxicity ag...»