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Complex #3390 — Ru(2) [K1]

2D Structure

Structure
⬇ MOL V3000

Info

ID3390
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 6}
AbbreviationK1
SMILESCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCn1ccnc1.[Cl-].c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1

TUCAN

C40H33ClFN9O2Ru/(1-34)(2-35)(3-37)(4-52)(5-38)(6-36)(7-58)(8-53)(9-56)(10-40)(11-57)(12-68)(13-46)(14-68)(15-68)(16-69)(17-47)(18-65)(19-44)(20-39)(21-54)(22-48)(23-69)(24-49)(25-42)(26-50)(27-55)(28-41)(29-43)(30-58)(31-66)(32-45)(33-75)(34-36)(34-37)(35-38)(35-40)(36-52)(37-59)(38-60)(39-41)(39-44)(40-53)(41-61)(42-43)(42-49)(43-62)(44-56)(45-63)(45-73)(46-64)(46-70)(47-48)(47-72)(48-63)(49-57)(50-51)(50-71)(51-64)(51-67)(52-77)(53-78)(54-55)(54-74)(55-76)(56-79)(57-81)(58-69)(58-76)(59-60)(59-77)(60-78)(61-62)(61-79)(62-81)(63-75)(64-82)(65-74)(65-76)(66-80)(66-82)(67-75)(67-80)(68-84)(69-83)(70-71)(70-84)(71-83)(72-73)(72-85)(73-86)(77-87)(78-87)(79-87)(80-87)(81-87)(82-87)

Measurements (4)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
MCF-731 10.1021/acs.inorgchem.6b00309 2016
A43138 10.1021/acs.inorgchem.6b00309 2016
A54940 10.1021/acs.inorgchem.6b00309 2016
HeLa74 10.1021/acs.inorgchem.6b00309 2016

🧬 Cell Death Types (1)

Apoptosis high
«Fluorescence-activated cell sorting (FACS) analysis by flow cytometry revealed that complex K4 (Figure 4d) induced mainly late-stage apoptosis and necrosis and showed much more overall cytotoxicity ag...»