Info
| ID | 3373 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 2 |
| SMILES | Cc1ccc(C(C)C)cc1.NS(=O)(=O)c1ccc(CCN=Cc2ncc[nH]2)cc1.[I-] |
TUCAN
C22H28N4O2RuS/(1-29)(2-36)(3-30)(4-35)(5-45)(6-32)(7-33)(8-48)(9-40)(10-46)(11-39)(12-40)(13-47)(14-34)(15-48)(16-30)(17-29)(18-30)(19-31)(20-38)(21-37)(22-31)(23-31)(24-29)(25-44)(26-52)(27-51)(28-52)(29-42)(30-44)(31-44)(32-33)(32-50)(33-41)(34-39)(34-50)(35-36)(35-42)(36-43)(37-38)(37-43)(38-42)(39-41)(40-41)(40-48)(43-44)(45-49)(45-53)(46-47)(46-54)(47-51)(48-53)(49-51)(49-54)(50-57)(52-57)(53-58)(54-58)(55-57)(56-57)(57-58)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MIA PaCa-2 | 17 | — | 10.1021/acs.inorgchem.0c03706 | 2021 |
| MDA-MB-231 | 40 | — | 10.1021/acs.inorgchem.0c03706 | 2021 |
| CHO | — | — | 10.1021/acs.inorgchem.0c03706 | 2021 |
| MDCK | — | — | 10.1021/acs.inorgchem.0c03706 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Both 1 and 2 induce apoptosis by depolarizing the mitochondrial membrane potential and arrest the cell cycle in the SubG1 phase.»