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Complex #333 — Ru(2) [Ru(bpy)2Cl2]

2D Structure

Structure
⬇ MOL V3000

Info

ID333
MetalRu
Oxidation state2
Charge0
Donor atoms{"N": 4}
AbbreviationRu(bpy)2Cl2
SMILES[Cl-].[Cl-].c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1

TUCAN

C20H16N4Ru/(1-29)(2-19)(3-21)(4-30)(5-31)(6-32)(7-24)(8-26)(9-17)(10-18)(11-22)(12-20)(13-23)(14-25)(15-28)(16-27)(17-18)(17-29)(18-19)(19-33)(20-21)(20-22)(21-34)(22-30)(23-24)(23-25)(24-35)(25-31)(26-27)(26-36)(27-28)(28-32)(29-37)(30-38)(31-39)(32-40)(33-34)(33-37)(34-38)(35-36)(35-39)(36-40)(37-41)(38-41)(39-41)(40-41)

Measurements (54)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
NCI-H22673— 10.1021/ic035390f 2004
A54973— 10.1039/c6cc04813g 2016
HL6096— 10.1039/c6cc04813g 2016
MCF-71e+02— 10.1021/ic035390f 2004
IGROV-11.1e+02— 10.1021/ic035390f 2004
M191.1e+02— 10.1021/ic035390f 2004
A4981.1e+02— 10.1021/ic035390f 2004
MCF-71.2e+02— 10.1021/ic035390f 2004
A3751.2e+02— 10.1016/j.ejmech.2014.05.040 2014
HEp-21.8e+02— 10.1016/j.ejmech.2014.05.040 2014
NIH-3T31.9e+02— 10.1016/j.ejmech.2014.05.040 2014
MGC-803—— 10.1016/j.ejmech.2022.114312 2022
T24—— 10.1016/j.ejmech.2022.114312 2022
HepG2—— 10.1016/j.ejmech.2022.114312 2022
BEL-7402—— 10.1016/j.ejmech.2022.114312 2022
HeLa—— 10.1016/j.ejmech.2022.114312 2022
SK-OV-3—— 10.1016/j.ejmech.2022.114312 2022
HL-7702—— 10.1016/j.ejmech.2022.114312 2022
HepG2—— 10.1002/smll.202310636 2024
A549—— 10.1002/smll.202310636 2024
B16-F10—— 10.1002/smll.202310636 2024
MCF-7—— 10.1002/smll.202310636 2024
HL-7702—— 10.1002/smll.202310636 2024
B16-F10—— 10.1007/s11243-024-00596-5 2024
CAL-27—— 10.1007/s11243-024-00596-5 2024
HL60—— 10.1007/s11243-024-00596-5 2024
HSC-3—— 10.1007/s11243-024-00596-5 2024
Jurkat—— 10.1007/s11243-024-00596-5 2024
KG-1a—— 10.1007/s11243-024-00596-5 2024
K-562—— 10.1007/s11243-024-00596-5 2024
NB4—— 10.1007/s11243-024-00596-5 2024
THP-1—— 10.1007/s11243-024-00596-5 2024
HepG2—— 10.1007/s11243-024-00596-5 2024
MRC-5—— 10.1007/s11243-024-00596-5 2024
B16-F10—— 10.1016/j.ica.2020.120125 2021
HCT-116—— 10.1016/j.ica.2020.120125 2021
HepG2—— 10.1016/j.ica.2020.120125 2021
MRC-5—— 10.1016/j.ica.2020.120125 2021
HepG2—— 10.1021/jm1009296 2010
HeLa—— 10.1021/jm1009296 2010
MCF-7—— 10.1021/jm1009296 2010
MCF-10A—— 10.1021/jm1009296 2010
ML2—— 10.1039/c7dt02255g 2017
HeLa—— 10.1016/j.ejmech.2014.05.040 2014
A549—— 10.1016/j.ejmech.2014.05.040 2014
HepG2—— 10.1016/j.ejmech.2014.05.040 2014
HeLa—— 10.1039/c1dt10084j 2011
HepG2—— 10.1039/c1dt10084j 2011
MCF-7—— 10.1039/c1dt10084j 2011
MCF-10A—— 10.1039/c1dt10084j 2011
EVSA-T—— 10.1021/ic035390f 2004
4T1—— 10.1039/d1dt01567b 2021
B16-F10—— 10.1039/d1dt01567b 2021
BHK-21—— 10.1039/d1dt01567b 2021

🧬 Cell Death Types (2)

Apoptosis high
«Furthermore, flow cytometry confirmed the mechanism of cell death for 2a occurs via apoptosis with no visible sign of necrosis.»
Immunogenic Cell Death high
«Several DNA-damaging antitumor agents, including ruthenium complexes, induce immunogenic cell death (ICD). ... KS-Ru translocates to the nucleus, causing DNA damage and inducing ICD.»