Info
| ID | 332 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | RPC2 |
| SMILES | c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C72H48N6Ru/(1-51)(2-52)(3-53)(4-58)(5-61)(6-60)(7-62)(8-49)(9-63)(10-67)(11-66)(12-68)(13-56)(14-71)(15-69)(16-65)(17-76)(18-82)(19-77)(20-73)(21-50)(22-79)(23-109)(24-74)(25-110)(26-57)(27-59)(28-75)(29-87)(30-64)(31-54)(32-111)(33-90)(34-55)(35-78)(36-112)(37-80)(38-81)(39-70)(40-83)(41-84)(42-85)(43-113)(44-89)(45-86)(46-72)(47-114)(48-88)(49-50)(49-95)(50-96)(51-53)(51-61)(52-91)(52-109)(53-60)(54-70)(54-102)(55-72)(55-104)(56-92)(56-110)(57-94)(57-111)(58-66)(58-68)(59-100)(59-112)(60-93)(61-62)(62-93)(63-66)(63-97)(64-103)(64-113)(65-69)(65-76)(67-68)(67-97)(69-71)(70-106)(71-98)(72-108)(73-76)(73-98)(74-77)(74-99)(75-79)(75-99)(77-82)(78-80)(78-101)(79-82)(80-87)(81-84)(81-101)(83-85)(83-107)(84-87)(85-89)(86-88)(86-107)(88-89)(90-105)(90-114)(91-93)(91-95)(92-96)(92-97)(94-98)(94-102)(95-115)(96-116)(99-100)(100-104)(101-103)(102-117)(103-106)(104-118)(105-107)(105-108)(106-119)(108-120)(109-121)(110-122)(111-123)(112-124)(113-125)(114-126)(115-116)(115-121)(116-122)(117-119)(117-123)(118-120)(118-124)(119-125)(120-126)(121-127)(122-127)(123-127)(124-127)(125-127)(126-127)
Measurements (21)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.62 | 0.11 | 10.1021/ic5013796 | 2014 |
| SF | 1 | — | 10.1016/j.jphotochem.2017.10.0... | 2018 |
| A549 | 1.2 | — | 10.1016/j.jinorgbio.2017.07.00... | 2017 |
| CT-26 | 1.2 | — | 10.1016/j.jinorgbio.2017.07.00... | 2017 |
| MCF-7 | 1.5 | — | 10.1039/C9SC05671H | 2020 |
| MCF-10A | 1.5 | — | 10.1039/C9SC05671H | 2020 |
| MCF-7 | 1.5 | — | 10.1002/cmdc.201700240 | 2017 |
| MCF-10A | 1.5 | — | 10.1002/cmdc.201700240 | 2017 |
| MCF-7 | 1.5 | — | 10.1002/cmdc.202300347 | 2023 |
| Jurkat | 1.6 | 0.075 | 10.1021/ic5013796 | 2014 |
| H358 | 1.7 | — | 10.1039/C9SC05671H | 2020 |
| H358 | 1.7 | — | 10.1002/cmdc.201700240 | 2017 |
| B16 | 1.7 | — | 10.1016/j.jphotochem.2017.10.0... | 2018 |
| H358 | 1.7 | — | 10.1002/cmdc.202300347 | 2023 |
| HUVEC | 2.8 | — | 10.1039/C9SC05671H | 2020 |
| ML2 | 2.9 | — | 10.1016/j.jphotochem.2017.10.0... | 2018 |
| MCF-7 | 3.6 | — | 10.1016/j.jphotochem.2017.10.0... | 2018 |
| HL60 | 3.8 | 0.35 | 10.1021/ic5013796 | 2014 |
| CCL228 | 4 | — | 10.1002/cmdc.201700240 | 2017 |
| MDA-MB-231 | 4 | — | 10.1016/j.jphotochem.2017.10.0... | 2018 |
| Caco-2 | — | — | 10.1016/j.jphotochem.2017.10.0... | 2018 |
🧬 Cell Death Types (2)
Apoptosis
high
«Compound 1 induced the proteolytic activation of both PARP and caspase 3 within 2 h of irradiation (Figure 4 A).»
Necroptosis
medium
«Exposure of HL60 cells to 1 produced this fragment at significant levels both when protected from light and when irradiated, which is consistent with necrosis.»