Info
| ID | 3249 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 7 |
| SMILES | c1ccc2c(c1)[nH]c1c(-c3nccs3)nccc12.c1cnc2c(ccc3nccnc32)n1.c1cnc2c(ccc3nccnc32)n1 |
TUCAN
C34H21N11RuS/(1-28)(2-42)(3-40)(4-35)(5-33)(6-41)(7-23)(8-54)(9-26)(10-25)(11-24)(12-22)(13-29)(14-30)(15-34)(16-36)(17-38)(18-39)(19-37)(20-27)(21-60)(22-23)(22-46)(23-45)(24-25)(24-26)(25-28)(26-31)(27-29)(27-51)(28-52)(29-47)(30-32)(30-37)(31-32)(31-52)(32-53)(33-38)(33-56)(34-39)(34-59)(35-40)(35-63)(36-41)(36-65)(37-66)(38-61)(39-62)(40-57)(41-58)(42-54)(42-64)(43-44)(43-46)(43-61)(44-45)(44-57)(45-63)(46-56)(47-50)(47-59)(48-53)(48-55)(48-66)(49-50)(49-51)(49-58)(50-62)(51-65)(52-60)(53-60)(54-67)(55-64)(55-67)(61-68)(62-68)(63-68)(64-68)(65-68)(66-68)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 32 | 6.8 | 10.1016/j.ejmech.2024.116618 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upon photoactivation, they generate ROS, leading to mitochondrial dysfunction and lysosomal damage and ultimately cell apoptosis.»