Info
| ID | 3248 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | 6 |
| SMILES | c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1.c1ccc2sc(-c3nccc4c3[nH]c3ccccc34)nc2c1 |
TUCAN
C38H27N7RuS/(1-51)(2-28)(3-40)(4-52)(5-34)(6-38)(7-53)(8-43)(9-44)(10-48)(11-32)(12-36)(13-46)(14-29)(15-33)(16-39)(17-41)(18-31)(19-35)(20-37)(21-54)(22-42)(23-30)(24-47)(25-45)(26-55)(27-66)(28-29)(28-40)(29-58)(30-37)(30-49)(31-39)(31-64)(32-33)(32-48)(33-59)(34-38)(34-57)(35-39)(35-41)(36-50)(36-54)(37-38)(40-51)(41-56)(42-46)(42-61)(43-46)(43-52)(44-47)(44-53)(45-47)(45-62)(48-55)(49-50)(49-57)(50-60)(51-68)(52-69)(53-70)(54-72)(55-71)(56-64)(56-67)(57-66)(58-59)(58-68)(59-71)(60-63)(60-66)(61-62)(61-69)(62-70)(63-65)(63-72)(64-73)(65-67)(65-73)(67-74)(68-74)(69-74)(70-74)(71-74)(72-74)(73-74)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 28 | 1.4 | 10.1016/j.ejmech.2024.116618 | 2024 |
| A549 | 35 | 1.8 | 10.1016/j.ejmech.2024.116618 | 2024 |
| PC-3 | 39 | 3.3 | 10.1016/j.ejmech.2024.116618 | 2024 |
| PC-3 | 39 | 5.5 | 10.1016/j.ejmech.2024.116618 | 2024 |
| PC-3 | 39 | 14 | 10.1016/j.ejmech.2024.116618 | 2024 |
| HeLa | 57 | 1.3 | 10.1016/j.ejmech.2024.116618 | 2024 |
| 1BR.3.G | 93 | 3.7 | 10.1016/j.ejmech.2024.116618 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upon photoactivation, they generate ROS, leading to mitochondrial dysfunction and lysosomal damage and ultimately cell apoptosis.»