Info
| ID | 3247 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | 5 |
| SMILES | Cc1csc(-c2nccc3c2[nH]c2ccccc23)n1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C35H27N7RuS/(1-31)(2-48)(3-33)(4-29)(5-36)(6-45)(7-32)(8-30)(9-49)(10-38)(11-39)(12-35)(13-34)(14-50)(15-42)(16-40)(17-28)(18-61)(19-51)(20-37)(21-43)(22-41)(23-44)(24-52)(25-28)(26-28)(27-63)(28-55)(29-30)(29-33)(30-53)(31-32)(31-39)(32-45)(33-48)(34-35)(34-36)(35-54)(36-49)(37-40)(37-50)(38-46)(38-51)(39-57)(40-42)(41-43)(41-44)(42-56)(43-52)(44-58)(45-47)(46-47)(46-60)(47-57)(48-64)(49-65)(50-66)(51-69)(52-67)(53-54)(53-64)(54-65)(55-61)(55-68)(56-58)(56-66)(57-63)(58-67)(59-60)(59-62)(59-69)(60-63)(61-70)(62-68)(62-70)(64-71)(65-71)(66-71)(67-71)(68-71)(69-71)(70-71)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 36 | 2.2 | 10.1016/j.ejmech.2024.116618 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upon photoactivation, they generate ROS, leading to mitochondrial dysfunction and lysosomal damage and ultimately cell apoptosis.»