Info
| ID | 3227 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 6} |
| Abbreviation | RuL2 |
| SMILES | COc1c[c-]c(-c2nc3cc4ccccc4cc3nc2-c2ccc(OC)cc2)cc1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C50H35N6O2Ru/(1-37)(2-55)(3-41)(4-38)(5-47)(6-56)(7-48)(8-59)(9-40)(10-43)(11-70)(12-45)(13-82)(14-82)(15-61)(16-46)(17-82)(18-39)(19-51)(20-44)(21-83)(22-83)(23-53)(24-54)(25-50)(26-71)(27-72)(28-58)(29-57)(30-83)(31-49)(32-73)(33-60)(34-42)(35-52)(36-46)(36-68)(37-40)(37-70)(38-39)(38-62)(39-63)(40-62)(41-43)(41-71)(42-50)(42-72)(43-63)(44-54)(44-84)(45-49)(45-64)(46-84)(47-48)(47-69)(48-56)(49-85)(50-65)(51-53)(51-65)(52-58)(52-73)(53-66)(54-68)(55-56)(55-67)(57-60)(57-64)(58-66)(59-69)(59-79)(60-85)(61-67)(61-78)(62-74)(63-75)(64-77)(65-76)(66-80)(67-69)(68-81)(70-86)(71-87)(72-88)(73-91)(74-75)(74-86)(75-87)(76-80)(76-88)(77-81)(77-89)(78-79)(78-90)(79-89)(80-91)(81-90)(82-92)(83-93)(84-92)(85-93)(86-94)(87-94)(88-94)(89-94)(90-94)(91-94)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 0.8 | 0.008 | 10.1021/acs.jmedchem.4c02357 | 2024 |
| HCT-116 | 0.8 | 0.08 | 10.1021/acs.jmedchem.4c02357 | 2024 |
| A375 | 1.2 | 0.023 | 10.1021/acs.jmedchem.4c02357 | 2024 |
| A375 | 1.2 | 0.07 | 10.1021/acs.jmedchem.4c02357 | 2024 |
| HeLa | 1.9 | 0.06 | 10.1021/acs.jmedchem.4c02357 | 2024 |
| HeLa | 1.9 | 0.13 | 10.1021/acs.jmedchem.4c02357 | 2024 |
| MRC5pd30 | 7 | — | 10.1021/acs.jmedchem.4c02357 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«the result suggests a caspase-dependent apoptosis as the predominant mode of cell death»