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Complex #3226 — Ru(2) [RuL1]

2D Structure

Structure
⬇ MOL V3000

Info

ID3226
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 6}
AbbreviationRuL1
SMILES[c-]1ccccc1-c1nc2cc3ccccc3cc2nc1-c1ccccc1.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12

TUCAN

C48H31N6Ru/(1-42)(2-40)(3-58)(4-48)(5-33)(6-46)(7-52)(8-34)(9-43)(10-36)(11-49)(12-59)(13-51)(14-44)(15-68)(16-69)(17-56)(18-57)(19-50)(20-35)(21-70)(22-53)(23-55)(24-45)(25-39)(26-38)(27-47)(28-71)(29-54)(30-37)(31-41)(32-35)(32-61)(33-34)(33-68)(34-60)(35-41)(36-48)(36-64)(37-38)(37-41)(38-61)(39-62)(39-74)(40-42)(40-58)(42-62)(43-47)(43-60)(44-45)(44-65)(45-66)(46-51)(46-69)(47-67)(48-50)(49-63)(49-79)(50-56)(51-65)(52-53)(52-70)(53-66)(54-55)(54-67)(55-71)(56-59)(57-58)(57-63)(59-64)(60-72)(61-75)(62-63)(64-77)(65-73)(66-76)(67-78)(68-80)(69-82)(70-83)(71-84)(72-78)(72-80)(73-76)(73-82)(74-79)(74-81)(75-77)(75-81)(76-83)(77-85)(78-84)(79-85)(80-86)(81-86)(82-86)(83-86)(84-86)(85-86)

Measurements (7)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
HCT-1160.90.045 10.1021/acs.jmedchem.4c02357 2024
HCT-1160.90.15 10.1021/acs.jmedchem.4c02357 2024
A3751.30.05 10.1021/acs.jmedchem.4c02357 2024
A3751.30.11 10.1021/acs.jmedchem.4c02357 2024
HeLa20.12 10.1021/acs.jmedchem.4c02357 2024
HeLa20.27 10.1021/acs.jmedchem.4c02357 2024
MRC5pd3012 10.1021/acs.jmedchem.4c02357 2024

🧬 Cell Death Types (1)

Apoptosis high
«the result suggests a caspase-dependent apoptosis as the predominant mode of cell death»