Info
| ID | 3176 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ru2 |
| SMILES | [c-]1cccc2c1c1ncccc1c1nc3ccc(-c4ccc5ccc6cccc7ccc4c5c67)cc3nc21.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C55H34N7Ru/(1-55)(2-40)(3-37)(4-41)(5-76)(6-46)(7-77)(8-51)(9-78)(10-45)(11-57)(12-62)(13-54)(14-43)(15-50)(16-48)(17-47)(18-61)(19-56)(20-38)(21-52)(22-53)(23-39)(24-79)(25-63)(26-36)(27-59)(28-80)(29-64)(30-49)(31-42)(32-44)(33-58)(34-60)(35-42)(35-68)(36-65)(36-81)(37-40)(37-41)(38-51)(38-52)(39-53)(39-57)(40-76)(41-83)(42-49)(43-50)(43-65)(44-64)(44-67)(45-62)(45-69)(46-55)(46-67)(47-48)(47-66)(48-79)(49-63)(50-84)(51-77)(52-86)(53-87)(54-61)(54-69)(55-56)(56-73)(57-78)(58-60)(58-89)(59-60)(59-80)(61-74)(62-73)(63-72)(64-75)(65-74)(66-85)(66-88)(67-71)(68-72)(68-88)(69-70)(70-71)(70-75)(71-73)(72-82)(74-75)(76-91)(77-92)(78-95)(79-94)(80-96)(81-84)(81-90)(82-85)(82-90)(83-86)(83-91)(84-93)(85-93)(86-92)(87-89)(87-95)(88-94)(89-96)(91-97)(92-97)(93-97)(94-97)(95-97)(96-97)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 11 | 8.3 | 10.1002/chem.202003031 | 2020 |
| MCF-7 | 15 | 12 | 10.1002/chem.202003031 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«This result also indicates that apoptosis, especially late apoptosis is the dominant cell death pathway.»