Info
| ID | 3175 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 8} |
| Abbreviation | Ru1 |
| SMILES | c1cc2ccc3ccc(-c4ccc5nc6c7cccnc7c7ncccc7c6nc5c4)c4ccc(c1)c2c34.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C54H34N8Ru/(1-60)(2-50)(3-46)(4-42)(5-45)(6-43)(7-73)(8-38)(9-78)(10-59)(11-74)(12-35)(13-36)(14-52)(15-77)(16-39)(17-37)(18-61)(19-41)(20-53)(21-47)(22-55)(23-44)(24-40)(25-54)(26-75)(27-56)(28-49)(29-62)(30-51)(31-58)(32-48)(33-57)(34-76)(35-36)(35-73)(36-38)(37-39)(37-47)(38-79)(39-80)(40-59)(40-60)(41-46)(41-65)(42-43)(42-68)(43-82)(44-54)(44-63)(45-61)(45-67)(46-64)(47-74)(48-55)(48-81)(49-55)(49-75)(50-53)(50-64)(51-52)(51-66)(52-78)(53-72)(54-70)(56-57)(56-58)(57-86)(58-76)(59-63)(60-72)(61-77)(62-68)(62-88)(63-71)(64-69)(65-68)(65-70)(66-83)(66-85)(67-84)(67-87)(69-70)(69-71)(71-72)(73-91)(74-92)(75-93)(76-94)(77-96)(78-90)(79-80)(79-91)(80-92)(81-86)(81-93)(82-88)(82-95)(83-87)(83-90)(84-85)(84-95)(85-89)(86-94)(87-96)(88-89)(91-97)(92-97)(93-97)(94-97)(95-97)(96-97)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 10 | 0.01 | 10.1002/chem.202003031 | 2020 |
| MCF-7 | 13 | 0.004 | 10.1002/chem.202003031 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«This result also indicates that apoptosis, especially late apoptosis is the dominant cell death pathway.»