Info
| ID | 3167 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 4} |
| Abbreviation | 4b |
| SMILES | O=[N+]([O-])c1cccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)c1.[Cl-].c1ccccc1 |
TUCAN
C25H17N5O2Ru/(1-18)(2-19)(3-20)(4-25)(5-31)(6-29)(7-22)(8-36)(9-26)(10-23)(11-21)(12-28)(13-30)(14-35)(15-24)(16-27)(17-44)(18-19)(18-20)(19-22)(20-23)(21-33)(21-41)(22-24)(23-24)(25-27)(25-32)(26-30)(26-33)(27-35)(28-29)(28-34)(29-36)(30-31)(31-41)(32-38)(32-39)(33-42)(34-37)(34-40)(35-47)(36-43)(37-38)(37-44)(38-46)(39-40)(39-47)(40-43)(41-45)(42-44)(42-46)(45-48)(45-49)(46-50)(47-50)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 92 | — | 10.3390/ma9050386 | 2016 |
| SMMC-7721 | — | — | 10.3390/ma9050386 | 2016 |
| SW620 | — | — | 10.3390/ma9050386 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis showed that apoptosis of A549 cells was observed following treatment with 1b. ... the level of apoptosis increased markedly, and reached a value of 28.2% for the 5 μM experime...»