Info
| ID | 3166 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"O": 1, "N": 4} |
| Abbreviation | 3b |
| SMILES | O=[N+]([O-])c1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.[Cl-].c1ccccc1 |
TUCAN
C25H17N5O2Ru/(1-18)(2-19)(3-20)(4-35)(5-25)(6-29)(7-22)(8-28)(9-26)(10-21)(11-23)(12-31)(13-30)(14-36)(15-24)(16-27)(17-44)(18-19)(18-20)(19-22)(20-23)(21-25)(21-33)(22-24)(23-24)(25-41)(26-27)(26-32)(27-35)(28-29)(28-36)(29-34)(30-31)(30-33)(31-41)(32-37)(32-38)(33-42)(34-39)(34-40)(35-46)(36-43)(37-40)(37-47)(38-39)(38-46)(39-43)(40-44)(41-45)(42-44)(42-47)(45-48)(45-49)(46-50)(47-50)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | — | — | 10.3390/ma9050386 | 2016 |
| SMMC-7721 | — | — | 10.3390/ma9050386 | 2016 |
| SW620 | — | — | 10.3390/ma9050386 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis showed that apoptosis of A549 cells was observed following treatment with 1b. ... the level of apoptosis increased markedly, and reached a value of 28.2% for the 5 μM experime...»
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