Info
| ID | 3165 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 2b |
| SMILES | Clc1cccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)c1.[Cl-].c1ccccc1 |
TUCAN
C25H17ClN4Ru/(1-19)(2-20)(3-35)(4-29)(5-21)(6-27)(7-31)(8-25)(9-22)(10-23)(11-18)(12-26)(13-30)(14-28)(15-24)(16-36)(17-44)(18-34)(18-42)(19-20)(19-21)(20-22)(21-23)(22-24)(23-24)(25-26)(25-35)(26-32)(27-28)(27-33)(28-36)(29-31)(29-34)(30-31)(30-42)(32-37)(32-39)(33-38)(33-40)(34-41)(35-46)(36-43)(37-40)(37-45)(38-39)(38-43)(39-46)(40-44)(41-44)(41-45)(42-47)(45-48)(46-48)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 27 | — | 10.3390/ma9050386 | 2016 |
| SMMC-7721 | — | — | 10.3390/ma9050386 | 2016 |
| SW620 | — | — | 10.3390/ma9050386 | 2016 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis showed that apoptosis of A549 cells was observed following treatment with 1b. ... the level of apoptosis increased markedly, and reached a value of 28.2% for the 5 μM experime...»