Info
| ID | 310 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5, "P": 1} |
| Abbreviation | Ru-IM-BODIPY (3b) |
| SMILES | CCC1=C(C)C2=C(c3ccc(C(=O)NCCNC(=O)c4ccc(P(=NC(=O)c5ccccn5)(c5ccccc5)c5ccccc5)cc4)cc3)c3c(C)c(CC)c(C)n3[B-](F)(F)[N+]2=C1C.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C61H64BF2N6O3PRu/(1-70)(2-69)(3-70)(4-70)(5-69)(6-71)(7-69)(8-88)(9-90)(10-71)(11-66)(12-67)(13-71)(14-76)(15-66)(16-74)(17-84)(18-87)(19-67)(20-78)(21-66)(22-68)(23-79)(24-114)(25-91)(26-74)(27-68)(28-67)(29-82)(30-89)(31-114)(32-98)(33-80)(34-115)(35-115)(36-92)(37-97)(38-81)(39-96)(40-83)(41-100)(42-100)(43-73)(44-86)(45-73)(46-95)(47-75)(48-73)(49-77)(50-68)(51-112)(52-93)(53-101)(54-72)(55-85)(56-99)(57-101)(58-74)(59-72)(60-72)(61-113)(62-94)(63-128)(64-127)(65-129)(65-130)(65-136)(65-137)(66-112)(67-103)(68-112)(69-104)(70-100)(71-117)(72-105)(73-101)(74-118)(75-76)(75-102)(76-103)(77-78)(77-102)(78-103)(79-84)(79-90)(80-90)(80-91)(81-92)(81-98)(82-89)(82-125)(83-85)(83-88)(84-124)(85-120)(86-87)(86-109)(87-106)(88-113)(89-111)(91-124)(92-96)(93-95)(93-106)(94-97)(94-125)(95-109)(96-99)(97-111)(98-126)(99-126)(100-107)(101-108)(102-112)(104-107)(104-116)(105-108)(105-119)(106-121)(107-117)(108-118)(109-110)(110-116)(110-119)(111-123)(113-131)(114-115)(114-127)(115-128)(116-129)(117-129)(118-130)(119-130)(120-122)(120-131)(121-127)(121-133)(122-132)(122-134)(123-128)(123-135)(124-138)(125-138)(126-138)(131-139)(132-138)(132-139)(138-139)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-10A | 73 | — | 10.1021/acs.inorgchem.1c02929 | 2021 |
| MDA-MB-231 | 1.2e+02 | — | 10.1021/acs.inorgchem.1c02929 | 2021 |
| IMR-90 | 1.8e+02 | — | 10.1021/acs.inorgchem.1c02929 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«We have demonstrated that Ru-IM (1) exerts canonical or caspase-dependent apoptosis»