Info
| ID | 3094 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | 3 |
| SMILES | Cc1c(C)c(C)c(C)c(C)c1C.O=C(CCC(=O)OCc1ccc(-c2nn(Cc3ccccc3)c3ccccc23)o1)Nc1cc2cccnc2c2ncccc12.[Cl-] |
TUCAN
C47H45N5O4Ru/(1-69)(2-46)(3-46)(4-46)(5-47)(6-47)(7-47)(8-81)(9-63)(10-62)(11-80)(12-56)(13-52)(14-58)(15-55)(16-53)(17-64)(18-65)(19-66)(20-69)(21-59)(22-88)(23-54)(24-82)(25-68)(26-67)(27-61)(28-57)(29-82)(30-60)(31-88)(32-68)(33-48)(34-48)(35-48)(36-49)(37-49)(38-49)(39-50)(40-50)(41-50)(42-51)(43-51)(44-51)(45-94)(46-72)(47-73)(48-74)(49-75)(50-76)(51-77)(52-53)(52-55)(53-57)(54-56)(54-80)(55-71)(56-70)(57-59)(58-63)(58-85)(59-71)(60-62)(60-78)(61-64)(61-79)(62-63)(64-81)(65-79)(65-86)(66-67)(66-89)(67-90)(68-69)(68-92)(69-91)(70-84)(70-86)(71-82)(72-73)(72-74)(73-75)(74-76)(75-77)(76-77)(78-85)(78-87)(79-83)(80-93)(81-96)(82-95)(83-84)(83-96)(84-93)(85-95)(86-94)(87-89)(87-97)(88-90)(88-101)(89-100)(90-100)(91-94)(91-99)(92-98)(92-101)(95-97)(96-102)(97-102)(100-102)(101-102)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 23 | — | 10.1021/acs.inorgchem.8b01070 | 2018 |
| A549 | 36 | — | 10.1021/acs.inorgchem.8b01070 | 2018 |
| HUVEC | 1.5e+02 | — | 10.1021/acs.inorgchem.8b01070 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Under normoxia, the apoptotic rates of HCT-116 cells treated with complexes 1−3 increased as compared with that of the untreated cells (Figure 6). Moreover, under a hypoxic condition, cells treated wi...»