Info
| ID | 3093 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | 2 |
| SMILES | O=C(CCC(=O)OCc1ccc(-c2nn(Cc3ccccc3)c3ccccc23)o1)Nc1cc2cccnc2c2ncccc12.[Cl-].c1ccccc1 |
TUCAN
C41H33N5O4Ru/(1-34)(2-47)(3-51)(4-35)(5-36)(6-38)(7-46)(8-64)(9-39)(10-62)(11-37)(12-48)(13-56)(14-56)(15-55)(16-49)(17-57)(18-44)(19-40)(20-54)(21-64)(22-52)(23-57)(24-50)(25-53)(26-41)(27-63)(28-45)(29-43)(30-70)(31-70)(32-42)(33-76)(34-35)(34-36)(35-37)(36-40)(37-41)(38-39)(38-62)(39-58)(40-41)(42-44)(42-65)(43-44)(43-53)(45-59)(45-66)(46-47)(46-61)(47-51)(48-51)(48-52)(49-50)(49-72)(50-71)(52-61)(53-60)(54-55)(54-59)(55-63)(56-57)(56-73)(57-74)(58-66)(58-68)(59-69)(60-65)(60-67)(61-64)(62-75)(63-78)(64-77)(65-77)(66-76)(67-72)(67-79)(68-69)(68-75)(69-78)(70-71)(70-83)(71-82)(72-82)(73-76)(73-81)(74-80)(74-83)(77-79)(78-84)(79-84)(82-84)(83-84)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 58 | — | 10.1021/acs.inorgchem.8b01070 | 2018 |
| A549 | 66 | — | 10.1021/acs.inorgchem.8b01070 | 2018 |
| HUVEC | 93 | — | 10.1021/acs.inorgchem.8b01070 | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«Under normoxia, the apoptotic rates of HCT-116 cells treated with complexes 1−3 increased as compared with that of the untreated cells (Figure 6). Moreover, under a hypoxic condition, cells treated wi...»