Info
| ID | 309 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"P": 1, "N": 3} |
| Abbreviation | Ru-IM-BODIPY (3a) |
| SMILES | CCC1=C(C)C2=C(c3ccc(P(=NC(=O)c4ccccn4)(c4ccccc4)c4ccccc4)cc3)c3c(C)c(CC)c(C)n3[B-](C)(C)[N+]2=C1C.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C53H60BN4OPRu/(1-85)(2-66)(3-84)(4-65)(5-70)(6-62)(7-64)(8-75)(9-64)(10-73)(11-74)(12-76)(13-66)(14-77)(15-66)(16-64)(17-71)(18-62)(19-67)(20-86)(21-67)(22-62)(23-104)(24-63)(25-67)(26-87)(27-79)(28-63)(29-63)(30-70)(31-65)(32-88)(33-68)(34-105)(35-90)(36-71)(37-82)(38-78)(39-81)(40-71)(41-65)(42-91)(43-69)(44-69)(45-94)(46-80)(47-70)(48-72)(49-72)(50-69)(51-94)(52-92)(53-68)(54-95)(55-68)(56-89)(57-93)(58-72)(59-95)(60-83)(61-62)(61-63)(61-115)(61-116)(64-104)(65-103)(66-107)(67-98)(68-110)(69-101)(70-94)(71-104)(72-95)(73-75)(73-96)(74-76)(74-96)(75-103)(76-103)(77-79)(77-112)(78-81)(78-105)(79-99)(80-83)(80-112)(81-82)(82-108)(83-99)(84-85)(84-88)(85-113)(86-87)(86-113)(87-88)(89-90)(89-114)(90-91)(91-92)(92-93)(93-114)(94-97)(95-102)(96-104)(97-98)(97-107)(98-106)(99-100)(100-106)(100-109)(101-102)(101-109)(102-110)(105-117)(106-115)(107-115)(108-111)(108-117)(109-116)(110-116)(111-118)(111-119)(112-120)(113-120)(114-120)(117-121)(118-120)(118-121)(120-121)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| IMR-90 | 60 | — | 10.1021/acs.inorgchem.1c02929 | 2021 |
| MCF-10A | 67 | — | 10.1021/acs.inorgchem.1c02929 | 2021 |
| MDA-MB-231 | 68 | — | 10.1021/acs.inorgchem.1c02929 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«We have demonstrated that Ru-IM (1) exerts canonical or caspase-dependent apoptosis»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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