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Complex #308 — Ru(2) [Ru-IM (1)]

2D Structure

Structure
⬇ MOL V3000

Info

ID308
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 2, "P": 1}
AbbreviationRu-IM (1)
SMILESCc1ccc(C(C)C)cc1.O=C(N=P(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccn1.[Cl-]

TUCAN

C34H33N2OPRu/(1-47)(2-43)(3-48)(4-35)(5-44)(6-35)(7-35)(8-39)(9-51)(10-41)(11-62)(12-37)(13-40)(14-46)(15-53)(16-55)(17-49)(18-50)(19-58)(20-52)(21-54)(22-56)(23-38)(24-36)(25-34)(26-36)(27-36)(28-34)(29-61)(30-45)(31-42)(32-34)(33-57)(34-59)(35-61)(36-61)(37-47)(37-65)(38-41)(38-63)(39-41)(39-62)(40-48)(40-65)(42-44)(42-59)(43-47)(43-48)(44-60)(45-57)(45-60)(46-51)(46-66)(49-51)(49-53)(50-55)(50-58)(52-53)(52-66)(54-55)(54-67)(56-58)(56-67)(57-59)(60-61)(62-68)(63-64)(63-68)(64-69)(64-70)(65-71)(66-71)(67-71)(68-72)(69-71)(69-72)(71-72)

Measurements (4)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
MCF-10A2.5 10.1021/acs.inorgchem.1c02929 2021
MDA-MB-2312.7 10.1021/acs.inorgchem.1c02929 2021
MDA-MB-2313.7 10.1021/acsptsci.4c00020 2024
IMR-9030 10.1021/acs.inorgchem.1c02929 2021

🧬 Cell Death Types (1)

Apoptosis high
«We have demonstrated that Ru-IM (1) exerts canonical or caspase-dependent apoptosis»