Info
| ID | 308 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | Ru-IM (1) |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(N=P(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccn1.[Cl-] |
TUCAN
C34H33N2OPRu/(1-47)(2-43)(3-48)(4-35)(5-44)(6-35)(7-35)(8-39)(9-51)(10-41)(11-62)(12-37)(13-40)(14-46)(15-53)(16-55)(17-49)(18-50)(19-58)(20-52)(21-54)(22-56)(23-38)(24-36)(25-34)(26-36)(27-36)(28-34)(29-61)(30-45)(31-42)(32-34)(33-57)(34-59)(35-61)(36-61)(37-47)(37-65)(38-41)(38-63)(39-41)(39-62)(40-48)(40-65)(42-44)(42-59)(43-47)(43-48)(44-60)(45-57)(45-60)(46-51)(46-66)(49-51)(49-53)(50-55)(50-58)(52-53)(52-66)(54-55)(54-67)(56-58)(56-67)(57-59)(60-61)(62-68)(63-64)(63-68)(64-69)(64-70)(65-71)(66-71)(67-71)(68-72)(69-71)(69-72)(71-72)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-10A | 2.5 | — | 10.1021/acs.inorgchem.1c02929 | 2021 |
| MDA-MB-231 | 2.7 | — | 10.1021/acs.inorgchem.1c02929 | 2021 |
| MDA-MB-231 | 3.7 | — | 10.1021/acsptsci.4c00020 | 2024 |
| IMR-90 | 30 | — | 10.1021/acs.inorgchem.1c02929 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«We have demonstrated that Ru-IM (1) exerts canonical or caspase-dependent apoptosis»