Info
| ID | 304 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 3, "S": 1, "P": 2} |
| Abbreviation | 3 |
| SMILES | CC(=N)C(C)=NN=C([S-])SCc1ccc(Cl)cc1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C48H43ClN3P2RuS2/(1-46)(2-47)(3-48)(4-50)(5-52)(6-53)(7-49)(8-51)(9-54)(10-56)(11-61)(12-89)(13-45)(14-55)(15-62)(16-63)(17-57)(18-64)(19-59)(20-58)(21-60)(22-65)(23-67)(24-66)(25-45)(26-44)(27-44)(28-44)(29-45)(30-68)(31-73)(32-74)(33-69)(34-70)(35-71)(36-72)(37-76)(38-77)(39-79)(40-75)(41-89)(42-78)(43-93)(44-81)(45-82)(46-47)(46-83)(47-50)(48-49)(48-83)(49-50)(51-52)(51-55)(52-84)(53-54)(53-84)(54-55)(56-59)(56-61)(57-59)(57-62)(58-63)(58-73)(60-64)(60-73)(61-85)(62-85)(63-86)(64-86)(65-66)(65-87)(66-74)(67-68)(67-87)(68-74)(69-70)(69-76)(70-88)(71-72)(71-88)(72-76)(75-77)(75-80)(77-91)(78-79)(78-80)(79-91)(80-89)(81-82)(81-93)(82-94)(83-95)(84-95)(85-95)(86-96)(87-96)(88-96)(89-98)(90-92)(90-97)(90-98)(91-99)(92-94)(93-100)(94-100)(95-100)(96-100)(98-100)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 6.9 | — | 10.1002/chem.202202694 | 2023 |
| HT-29 | 14 | — | 10.1002/chem.202202694 | 2023 |
| NIH-3T3 | 37 | — | 10.1002/chem.202202694 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, an apoptotic mechanism of cell death was confirmed by cell cycle analysis and Annexin V-FITC/PI double staining techniques. In this regard, the live cell confocal microscopy results revealed ...»