Info
| ID | 3023 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | 1 |
| SMILES | Nc1ccc(-c2ccc3nc4c5cccnc5c5ncccc5c4nc3c2)cc1N.c1cnc2c(c1)ccc1cccnc12.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C48H32N10Ru/(1-52)(2-51)(3-63)(4-64)(5-45)(6-37)(7-34)(8-33)(9-35)(10-46)(11-43)(12-66)(13-67)(14-47)(15-41)(16-54)(17-40)(18-42)(19-48)(20-36)(21-44)(22-38)(23-65)(24-50)(25-53)(26-68)(27-39)(28-49)(29-81)(30-82)(31-82)(32-81)(33-34)(33-63)(34-55)(35-43)(35-56)(36-47)(36-57)(37-38)(37-55)(38-56)(39-49)(39-57)(40-54)(40-58)(41-42)(41-59)(42-65)(43-64)(44-48)(44-62)(45-61)(45-72)(46-60)(46-80)(47-66)(48-67)(49-62)(50-53)(50-79)(51-52)(51-61)(52-73)(53-60)(54-68)(55-69)(56-70)(57-71)(58-76)(58-78)(59-74)(59-75)(60-61)(62-77)(63-85)(64-86)(65-83)(66-87)(67-88)(68-90)(69-70)(69-85)(70-86)(71-77)(71-87)(72-73)(72-81)(73-82)(74-78)(74-83)(75-76)(75-84)(76-89)(77-88)(78-90)(79-80)(79-89)(80-84)(85-91)(86-91)(87-91)(88-91)(89-91)(90-91)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 11 | — | 10.1039/c2dt12402e | 2012 |
| HepG2 | 13 | — | 10.1039/c2dt12402e | 2012 |
🧬 Cell Death Types (1)
Apoptosis
high
«the majority of the HepG2 cells treated with either complex 1 or 2 displayed the classic morphological features of apoptosis after exposure to 20 μM of the complexes, including nuclear condensation, c...»