Info
| ID | 302 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 3, "S": 1, "P": 2} |
| Abbreviation | 1 |
| SMILES | CC(=N)C(C)=NN=C([S-])SCc1ccccc1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C48H44N3P2RuS2/(1-47)(2-50)(3-48)(4-51)(5-53)(6-49)(7-52)(8-58)(9-54)(10-56)(11-57)(12-55)(13-63)(14-61)(15-59)(16-60)(17-66)(18-62)(19-68)(20-73)(21-64)(22-67)(23-65)(24-91)(25-46)(26-46)(27-46)(28-91)(29-69)(30-74)(31-70)(32-71)(33-75)(34-81)(35-76)(36-72)(37-78)(38-77)(39-45)(40-45)(41-79)(42-80)(43-45)(44-94)(45-83)(46-84)(47-48)(47-50)(48-85)(49-50)(49-51)(51-85)(52-53)(52-63)(53-86)(54-58)(54-86)(55-59)(55-87)(56-57)(56-80)(57-65)(58-63)(59-64)(60-61)(60-64)(61-87)(62-66)(62-88)(65-82)(66-69)(67-68)(67-69)(68-88)(70-73)(70-76)(71-74)(71-76)(72-75)(72-78)(73-89)(74-89)(75-90)(77-78)(77-81)(79-80)(79-82)(81-90)(82-91)(83-84)(83-94)(84-95)(85-96)(86-96)(87-96)(88-97)(89-97)(90-97)(91-99)(92-93)(92-98)(92-99)(93-95)(94-100)(95-100)(96-100)(97-100)(99-100)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 12 | — | 10.1002/chem.202202694 | 2023 |
| HT-29 | 33 | — | 10.1002/chem.202202694 | 2023 |
| NIH-3T3 | 46 | — | 10.1002/chem.202202694 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Further, an apoptotic mechanism of cell death was confirmed by cell cycle analysis and Annexin V-FITC/PI double staining techniques. In this regard, the live cell confocal microscopy results revealed ...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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