Info
| ID | 3003 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | RuL |
| SMILES | Cc1ccc(C(C)C)cc1.[Cl-].c1ccc2c(-c3ccc4nc5c6cccnc6c6ncccc6c5nc4c3)cccc2c1 |
TUCAN
C38H30N4Ru/(1-50)(2-34)(3-40)(4-32)(5-32)(6-31)(7-37)(8-43)(9-46)(10-51)(11-39)(12-44)(13-45)(14-62)(15-35)(16-38)(17-49)(18-61)(19-47)(20-36)(21-31)(22-32)(23-33)(24-41)(25-48)(26-33)(27-33)(28-31)(29-60)(30-42)(31-52)(32-60)(33-60)(34-38)(34-58)(35-47)(35-59)(36-39)(36-62)(37-45)(37-61)(38-63)(39-57)(40-41)(40-52)(41-54)(42-48)(42-54)(43-50)(43-55)(44-47)(44-55)(45-56)(46-58)(46-67)(48-52)(49-50)(49-51)(51-53)(53-55)(53-59)(54-60)(56-65)(56-68)(57-64)(57-66)(58-59)(61-70)(62-72)(63-67)(63-71)(64-68)(64-71)(65-66)(65-70)(66-72)(67-69)(68-69)(71-73)(72-73)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116CD44+ | 6.5 | — | 10.1021/acsabm.2c00556 | 2023 |
🧬 Cell Death Types (2)
Apoptosis
high
«The level of BAX and Bcl-2 was further quantified by qRT-PCR. The expression of proapoptotic BAX showed increased expression in the complex IrL-treated cell compared to the control, indicating the pot...»
Autophagy
high
«Upon further validation, complex IrL was developed as an inhibitor of autophagy for the eradication of cancer stem cells.»