Info
| ID | 2998 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru4 |
| SMILES | CC#N.CC#N.[c-]1n(Cc2ccccc2)c2ccccc2[n+]1-c1ccccn1.c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C47H37N7Ru/(1-64)(2-44)(3-38)(4-38)(5-38)(6-52)(7-42)(8-40)(9-43)(10-55)(11-51)(12-47)(13-50)(14-41)(15-77)(16-75)(17-53)(18-56)(19-57)(20-60)(21-49)(22-78)(23-78)(24-65)(25-48)(26-54)(27-58)(28-45)(29-62)(30-63)(31-46)(32-76)(33-59)(34-61)(35-39)(36-39)(37-39)(38-73)(39-74)(40-44)(40-67)(41-66)(41-75)(42-44)(42-56)(43-56)(43-67)(45-59)(45-69)(46-47)(46-62)(47-82)(48-50)(48-84)(49-52)(49-68)(50-51)(51-77)(52-64)(53-72)(53-76)(54-57)(54-60)(55-57)(55-71)(58-60)(58-71)(59-70)(61-62)(61-80)(63-64)(63-65)(65-68)(66-67)(66-69)(68-78)(69-79)(70-72)(70-81)(71-72)(73-85)(74-86)(75-89)(76-90)(77-91)(78-87)(79-81)(79-89)(80-82)(80-88)(81-90)(82-87)(83-87)(83-88)(84-88)(84-91)(89-92)(90-92)(91-92)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 3.1 | — | 10.1039/d2dt03405k | 2023 |
| HCT-116 | 3.5 | — | 10.1039/d2dt03405k | 2023 |
| HT-29 | 3.8 | — | 10.1039/d2dt03405k | 2023 |
| ES-2 | 3.9 | — | 10.1039/d2dt03405k | 2023 |
| BEL-7402 | 4.6 | — | 10.1039/d2dt03405k | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies showed that Ru3 and Ru4 caused a dual action mode of mitochondrial membrane depolarization and endoplasmic reticulum stress and finally induced apoptosis of HeLa cells.»