Info
| ID | 2997 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru3 |
| SMILES | CC#N.CC#N.Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C.[c-]1n(Cc2ccccc2)c2ccccc2[n+]1-c1ccccn1 |
TUCAN
C39H37N7Ru/(1-67)(2-50)(3-38)(4-51)(5-38)(6-45)(7-48)(8-42)(9-38)(10-70)(11-44)(12-47)(13-42)(14-69)(15-39)(16-39)(17-39)(18-40)(19-40)(20-40)(21-56)(22-52)(23-46)(24-70)(25-42)(26-43)(27-43)(28-53)(29-55)(30-49)(31-54)(32-68)(33-43)(34-57)(35-41)(36-41)(37-41)(38-59)(39-65)(40-66)(41-63)(42-62)(43-64)(44-45)(44-68)(45-49)(46-50)(46-72)(47-48)(47-52)(48-55)(49-76)(50-51)(51-54)(52-60)(53-55)(53-60)(54-74)(56-57)(56-58)(57-61)(58-62)(58-71)(59-62)(59-67)(60-70)(61-64)(61-73)(63-64)(63-69)(65-77)(66-78)(67-81)(68-82)(69-83)(70-80)(71-73)(71-81)(72-74)(72-79)(73-83)(74-80)(75-79)(75-80)(76-79)(76-82)(81-84)(82-84)(83-84)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 2.8 | — | 10.1039/d2dt03405k | 2023 |
| HeLa | 4.3 | — | 10.1039/d2dt03405k | 2023 |
| ES-2 | 5 | — | 10.1039/d2dt03405k | 2023 |
| HT-29 | 5.3 | — | 10.1039/d2dt03405k | 2023 |
| BEL-7402 | 7.2 | — | 10.1039/d2dt03405k | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«HeLa cells were seeded... Then, the cells were incubated with Ru3, Ru4 and cisplatin (4 μM) for another 24 h. ... The cell apoptosis analysis was determined by an Alexa Fluor 488 annexin V/PI apoptosi...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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