Info
| ID | 2997 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru3 |
| SMILES | CC#N.CC#N.Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C.[c-]1n(Cc2ccccc2)c2ccccc2[n+]1-c1ccccn1 |
TUCAN
C39H37N7Ru/(1-67)(2-50)(3-38)(4-51)(5-38)(6-45)(7-48)(8-42)(9-38)(10-70)(11-44)(12-47)(13-42)(14-69)(15-39)(16-39)(17-39)(18-40)(19-40)(20-40)(21-56)(22-52)(23-46)(24-70)(25-42)(26-43)(27-43)(28-53)(29-55)(30-49)(31-54)(32-68)(33-43)(34-57)(35-41)(36-41)(37-41)(38-59)(39-65)(40-66)(41-63)(42-62)(43-64)(44-45)(44-68)(45-49)(46-50)(46-72)(47-48)(47-52)(48-55)(49-76)(50-51)(51-54)(52-60)(53-55)(53-60)(54-74)(56-57)(56-58)(57-61)(58-62)(58-71)(59-62)(59-67)(60-70)(61-64)(61-73)(63-64)(63-69)(65-77)(66-78)(67-81)(68-82)(69-83)(70-80)(71-73)(71-81)(72-74)(72-79)(73-83)(74-80)(75-79)(75-80)(76-79)(76-82)(81-84)(82-84)(83-84)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 2.8 | — | 10.1039/d2dt03405k | 2023 |
| HeLa | 4.3 | — | 10.1039/d2dt03405k | 2023 |
| ES-2 | 5 | — | 10.1039/d2dt03405k | 2023 |
| HT-29 | 5.3 | — | 10.1039/d2dt03405k | 2023 |
| BEL-7402 | 7.2 | — | 10.1039/d2dt03405k | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies showed that Ru3 and Ru4 caused a dual action mode of mitochondrial membrane depolarization and endoplasmic reticulum stress and finally induced apoptosis of HeLa cells.»