Info
| ID | 2996 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru2 |
| SMILES | CC#N.CC#N.[c-]1n(Cc2ccccc2)c2ccccc2[n+]1-c1ccccn1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C35H29N7Ru/(1-36)(2-30)(3-30)(4-30)(5-56)(6-38)(7-41)(8-46)(9-32)(10-58)(11-58)(12-35)(13-42)(14-34)(15-55)(16-44)(17-49)(18-57)(19-31)(20-31)(21-31)(22-33)(23-37)(24-40)(25-47)(26-48)(27-39)(28-45)(29-43)(30-53)(31-54)(32-33)(32-35)(33-64)(34-36)(34-56)(35-55)(36-50)(37-43)(37-57)(38-42)(38-50)(39-40)(39-61)(40-49)(41-46)(41-48)(42-51)(43-51)(44-46)(44-52)(45-49)(45-62)(47-48)(47-52)(50-59)(51-60)(52-58)(53-65)(54-66)(55-69)(56-70)(57-71)(58-68)(59-60)(59-70)(60-71)(61-62)(61-68)(62-67)(63-67)(63-68)(64-67)(64-69)(69-72)(70-72)(71-72)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 37 | — | 10.1039/d2dt03405k | 2023 |
| HT-29 | 38 | — | 10.1039/d2dt03405k | 2023 |
| ES-2 | 49 | — | 10.1039/d2dt03405k | 2023 |
| HeLa | 60 | — | 10.1039/d2dt03405k | 2023 |
| BEL-7402 | — | — | 10.1039/d2dt03405k | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies showed that Ru3 and Ru4 caused a dual action mode of mitochondrial membrane depolarization and endoplasmic reticulum stress and finally induced apoptosis of HeLa cells.»