Info
| ID | 2995 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru1 |
| SMILES | CC#N.CC#N.CC#N.CC#N.[c-]1n(Cc2ccccc2)c2ccccc2[n+]1-c1ccccn1 |
TUCAN
C27N7Ru/(1-18)(2-19)(3-20)(4-21)(5-7)(5-9)(6-16)(6-27)(7-8)(8-15)(9-17)(10-13)(10-14)(11-16)(11-22)(12-13)(12-25)(14-24)(15-17)(17-23)(18-28)(19-29)(20-30)(21-31)(22-32)(23-34)(24-25)(24-33)(25-34)(26-33)(26-34)(27-32)(27-33)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | — | — | 10.1039/d2dt03405k | 2023 |
| HCT-116 | — | — | 10.1039/d2dt03405k | 2023 |
| HT-29 | — | — | 10.1039/d2dt03405k | 2023 |
| ES-2 | — | — | 10.1039/d2dt03405k | 2023 |
| BEL-7402 | — | — | 10.1039/d2dt03405k | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mechanistic studies showed that Ru3 and Ru4 caused a dual action mode of mitochondrial membrane depolarization and endoplasmic reticulum stress and finally induced apoptosis of HeLa cells.»