Info
| ID | 298 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 1, "P": 1} |
| Abbreviation | Ru2 |
| SMILES | CC(C)c1cc(S(=O)(=O)[O-])cc(C(C)C)c1N=Cc1ccccc1P(c1ccccc1)c1ccccc1.[Cl-].c1ccccc1 |
TUCAN
C37H37NO3PRuS/(1-67)(2-51)(3-38)(4-49)(5-54)(6-42)(7-43)(8-44)(9-45)(10-50)(11-55)(12-59)(13-38)(14-38)(15-46)(16-52)(17-56)(18-39)(19-58)(20-60)(21-47)(22-63)(23-69)(24-39)(25-39)(26-57)(27-61)(28-40)(29-40)(30-40)(31-62)(32-68)(33-48)(34-41)(35-41)(36-41)(37-53)(38-67)(39-67)(40-68)(41-68)(42-43)(42-44)(43-45)(44-46)(45-47)(46-47)(48-64)(48-74)(49-51)(49-52)(50-52)(50-54)(51-71)(53-65)(53-74)(54-71)(55-59)(55-72)(56-58)(56-62)(57-63)(57-72)(58-66)(59-60)(60-63)(61-62)(61-73)(64-67)(64-70)(65-68)(65-70)(66-69)(66-73)(69-75)(70-75)(71-79)(72-79)(73-79)(74-80)(75-81)(76-80)(77-80)(78-80)(79-81)(80-81)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 80 | — | 10.1021/acs.inorgchem.2c03279 | 2022 |
| A549 | 91 | — | 10.1021/acs.inorgchem.2c03279 | 2022 |
| BEAS-2B | 98 | — | 10.1021/acs.inorgchem.2c03279 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«The flow cytometry studies indicated that the representative complex Ir1 could induce early-stage apoptosis in A549 cells.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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