Info
| ID | 293 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 8} |
| Abbreviation | RUNAT-BI |
| SMILES | [Cl-].[Cl-].c1c[nH]c(-c2ncc[nH]2)n1.c1c[nH]c(-c2ncc[nH]2)n1 |
TUCAN
C12H12N8Ru/(1-13)(2-16)(3-17)(4-14)(5-19)(6-15)(7-18)(8-20)(9-25)(10-26)(11-27)(12-28)(13-14)(13-25)(14-29)(15-16)(15-30)(16-26)(17-18)(17-27)(18-31)(19-20)(19-28)(20-32)(21-22)(21-25)(21-29)(22-26)(22-30)(23-24)(23-27)(23-31)(24-28)(24-32)(29-33)(30-33)(31-33)(32-33)
Measurements (16)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116 | 16 | — | 10.3390/cancers15010069 | 2022 |
| HCT-116 | 22 | — | 10.3390/cancers15010069 | 2022 |
| HCC1806 | 25 | — | 10.3390/cancers15010069 | 2022 |
| HCC1806 | 28 | — | 10.3390/cancers15010069 | 2022 |
| AGS | 30 | — | 10.3390/cancers15010069 | 2022 |
| BT-474 | 33 | — | 10.3390/cancers15010069 | 2022 |
| AGS | 44 | — | 10.3390/cancers15010069 | 2022 |
| MDA-MB-231 | 49 | — | 10.3390/cancers15010069 | 2022 |
| MCF-7 | 49 | — | 10.3390/cancers15010069 | 2022 |
| HCC1937 | 66 | — | 10.3390/cancers15010069 | 2022 |
| BT-474 | 69 | — | 10.3390/cancers15010069 | 2022 |
| HCC1500 | 76 | — | 10.3390/cancers15010069 | 2022 |
| HCC1937 | 94 | — | 10.3390/cancers15010069 | 2022 |
| MDA-MB-231 | 1.1e+02 | — | 10.3390/cancers15010069 | 2022 |
| HCC1500 | 1.9e+02 | — | 10.3390/cancers15010069 | 2022 |
| MCF-7 | 2.7e+02 | — | 10.3390/cancers15010069 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
medium
«Our results indicated an increase in BAX and CASPASE-3 in most cell lines treated with Runat-BI compared with control samples»