Info
| ID | 2923 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 7} |
| Abbreviation | Ru3 |
| SMILES | [Cl-].c1ccc(-c2cc(-c3ccccn3)nc(-c3ccccn3)c2)cc1.c1ccc2c(-c3nc4c5cccnc5c5ncccc5c4[nH]3)c3ccccc3cc2c1 |
TUCAN
C48H31N7Ru/(1-70)(2-57)(3-68)(4-53)(5-35)(6-51)(7-36)(8-49)(9-41)(10-54)(11-46)(12-42)(13-39)(14-38)(15-69)(16-43)(17-33)(18-48)(19-34)(20-50)(21-67)(22-37)(23-32)(24-47)(25-52)(26-55)(27-44)(28-45)(29-56)(30-40)(31-82)(32-37)(32-62)(33-34)(33-58)(34-67)(35-37)(35-48)(36-53)(36-68)(38-41)(38-46)(39-41)(39-66)(40-45)(40-70)(42-45)(42-72)(43-46)(43-66)(44-57)(44-69)(47-52)(47-63)(48-59)(49-50)(49-52)(50-60)(51-59)(51-60)(53-61)(54-57)(54-78)(55-65)(55-77)(56-65)(56-76)(58-71)(58-75)(59-62)(60-63)(61-73)(61-74)(62-64)(63-64)(64-79)(65-66)(67-80)(68-83)(69-81)(70-86)(71-73)(71-80)(72-76)(72-86)(73-83)(74-75)(74-84)(75-82)(76-85)(77-78)(77-85)(78-81)(79-82)(79-84)(83-87)(84-87)(85-87)(86-87)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 66 | 0.75 | 10.1021/acs.inorgchem.4c00650 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«The cell death mechanistic study revealed that Ru3 induced ROS-mediated apoptosis in HeLa cells via mitochondrial depolarization under white or green light exposure.»