Info
| ID | 2914 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 3 |
| SMILES | Cc1ccccc1.Clc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.[Cl-] |
TUCAN
C26H19ClN4Ru/(1-20)(2-29)(3-39)(4-38)(5-30)(6-31)(7-22)(8-32)(9-28)(10-33)(11-21)(12-24)(13-20)(14-25)(15-26)(16-20)(17-23)(18-27)(19-47)(20-36)(21-28)(21-37)(22-31)(22-35)(23-24)(23-36)(24-26)(25-26)(25-27)(27-36)(28-39)(29-30)(29-45)(30-34)(31-38)(32-33)(32-45)(33-34)(34-44)(35-40)(35-41)(37-42)(37-43)(38-49)(39-46)(40-42)(40-48)(41-43)(41-49)(42-47)(43-46)(44-47)(44-48)(45-50)(48-51)(49-51)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 44 | — | 10.3390/molecules27103046 | 2022 |
| MCF-7 | — | — | 10.3390/molecules27103046 | 2022 |
| EC-1 | — | — | 10.3390/molecules27103046 | 2022 |
| MCF-10A | — | — | 10.3390/molecules27103046 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis, comet assay, and immunofluorescence confirm that 1 can induce the apoptosis of MCF-7 cells and G0/G1 phase arrest through DNA damage.»