Info
| ID | 2913 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 2 |
| SMILES | Cc1ccccc1.Clc1cccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)c1.[Cl-] |
TUCAN
C26H19ClN4Ru/(1-20)(2-20)(3-28)(4-38)(5-29)(6-23)(7-30)(8-21)(9-32)(10-39)(11-33)(12-22)(13-24)(14-25)(15-31)(16-26)(17-27)(18-20)(19-47)(20-36)(21-33)(21-34)(22-30)(22-39)(23-29)(23-35)(24-25)(24-36)(25-27)(26-27)(26-31)(28-34)(28-45)(29-38)(30-37)(31-36)(32-33)(32-45)(34-44)(35-40)(35-43)(37-41)(37-42)(38-49)(39-46)(40-41)(40-48)(41-47)(42-43)(42-46)(43-49)(44-47)(44-48)(45-50)(48-51)(49-51)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| EC-1 | 75 | — | 10.3390/molecules27103046 | 2022 |
| MDA-MB-231 | 93 | — | 10.3390/molecules27103046 | 2022 |
| MCF-7 | — | — | 10.3390/molecules27103046 | 2022 |
| MCF-10A | — | — | 10.3390/molecules27103046 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis, comet assay, and immunofluorescence confirm that 1 can induce the apoptosis of MCF-7 cells and G0/G1 phase arrest through DNA damage.»