Info
| ID | 2912 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 1 |
| SMILES | Cc1ccccc1.Clc1ccccc1-c1nc2c3cccnc3c3ncccc3c2[nH]1.[Cl-] |
TUCAN
C26H19ClN4Ru/(1-20)(2-20)(3-29)(4-22)(5-28)(6-23)(7-30)(8-21)(9-32)(10-39)(11-33)(12-38)(13-20)(14-27)(15-25)(16-24)(17-26)(18-31)(19-47)(20-36)(21-23)(21-33)(22-29)(22-35)(23-34)(24-25)(24-36)(25-27)(26-27)(26-31)(28-30)(28-37)(29-39)(30-38)(31-36)(32-33)(32-45)(34-44)(34-45)(35-40)(35-43)(37-41)(37-42)(38-46)(39-49)(40-42)(40-48)(41-43)(41-46)(42-47)(43-49)(44-47)(44-48)(45-50)(48-51)(49-51)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 3.7 | — | 10.3390/molecules27103046 | 2022 |
| EC-1 | 71 | — | 10.3390/molecules27103046 | 2022 |
| MDA-MB-231 | — | — | 10.3390/molecules27103046 | 2022 |
| MCF-10A | — | — | 10.3390/molecules27103046 | 2022 |
🧬 Cell Death Types (1)
Apoptosis
high
«Flow cytometric analysis, comet assay, and immunofluorescence confirm that 1 can induce the apoptosis of MCF-7 cells and G0/G1 phase arrest through DNA damage.»