Info
| ID | 2911 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 7 |
| SMILES | CCOC(=O)c1ccnc(-c2cc(C(=O)OCC)ccn2)c1.[Cl-].c1ccccc1 |
TUCAN
C22H22N2O4Ru/(1-23)(2-25)(3-26)(4-32)(5-41)(6-31)(7-27)(8-23)(9-23)(10-28)(11-29)(12-24)(13-41)(14-37)(15-30)(16-24)(17-33)(18-38)(19-42)(20-24)(21-42)(22-34)(23-41)(24-42)(25-26)(25-27)(26-28)(27-29)(28-30)(29-30)(31-35)(31-39)(32-35)(32-37)(33-36)(33-40)(34-36)(34-38)(35-43)(36-44)(37-45)(38-46)(39-40)(39-45)(40-46)(41-49)(42-50)(43-47)(43-49)(44-48)(44-50)(45-51)(46-51)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 20 | — | 10.3390/ijms241511896 | 2023 |
| EA.hy926 | 24 | — | 10.3390/ijms241511896 | 2023 |
| Vero | 34 | — | 10.3390/ijms241511896 | 2023 |
| HepG2 | 42 | — | 10.3390/ijms241511896 | 2023 |
| MCF-10A | — | — | 10.3390/ijms241511896 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Fluorescence imaging and flow cytometry analysis demonstrate that 1 and 2 effectively penetrate the membrane and promote T24 cell death through the apoptotic pathway, mainly inducing early apoptosis o...»