Info
| ID | 2910 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 6 |
| SMILES | COC(=O)c1ccnc(-c2cc(C(=O)OC)ccn2)c1.[Cl-].c1ccccc1 |
TUCAN
C20H18N2O4Ru/(1-19)(2-20)(3-25)(4-26)(5-27)(6-21)(7-35)(8-35)(9-22)(10-23)(11-31)(12-32)(13-24)(14-35)(15-28)(16-36)(17-36)(18-36)(19-20)(19-21)(20-22)(21-23)(22-24)(23-24)(25-29)(25-31)(26-29)(26-33)(27-30)(27-34)(28-30)(28-32)(29-37)(30-38)(31-39)(32-40)(33-34)(33-39)(34-40)(35-43)(36-44)(37-41)(37-43)(38-42)(38-44)(39-45)(40-45)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 14 | — | 10.3390/ijms241511896 | 2023 |
| T24 | 41 | — | 10.3390/ijms241511896 | 2023 |
| Vero | 49 | — | 10.3390/ijms241511896 | 2023 |
| EA.hy926 | 49 | — | 10.3390/ijms241511896 | 2023 |
| MCF-10A | — | — | 10.3390/ijms241511896 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Fluorescence imaging and flow cytometry analysis demonstrate that 1 and 2 effectively penetrate the membrane and promote T24 cell death through the apoptotic pathway, mainly inducing early apoptosis o...»