Info
| ID | 2908 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 4 |
| SMILES | CCOC(=O)c1ccnc(-c2cc(C(=O)OCC)ccn2)c1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C26H30N2O4Ru/(1-34)(2-48)(3-37)(4-31)(5-31)(6-32)(7-31)(8-41)(9-32)(10-33)(11-33)(12-36)(13-38)(14-34)(15-32)(16-33)(17-39)(18-49)(19-53)(20-42)(21-53)(22-34)(23-35)(24-54)(25-50)(26-35)(27-54)(28-40)(29-43)(30-35)(31-48)(32-44)(33-48)(34-53)(35-54)(36-37)(36-45)(37-44)(38-41)(38-45)(39-46)(39-51)(40-47)(40-52)(41-44)(42-46)(42-49)(43-47)(43-50)(45-48)(46-55)(47-56)(49-57)(50-58)(51-52)(51-57)(52-58)(53-61)(54-62)(55-59)(55-61)(56-60)(56-62)(57-63)(58-63)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 12 | — | 10.3390/ijms241511896 | 2023 |
| HepG2 | 21 | — | 10.3390/ijms241511896 | 2023 |
| Vero | 31 | — | 10.3390/ijms241511896 | 2023 |
| EA.hy926 | 32 | — | 10.3390/ijms241511896 | 2023 |
| MCF-10A | 40 | — | 10.3390/ijms241511896 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Fluorescence imaging and flow cytometry analysis demonstrate that 1 and 2 effectively penetrate the membrane and promote T24 cell death through the apoptotic pathway, mainly inducing early apoptosis o...»