Info
| ID | 2907 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 2 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(O)c1ccnc(-c2cc(C(=O)O)ccn2)c1.[Cl-] |
TUCAN
C22H22N2O4Ru/(1-29)(2-28)(3-23)(4-23)(5-24)(6-23)(7-27)(8-33)(9-26)(10-32)(11-39)(12-40)(13-24)(14-30)(15-24)(16-38)(17-25)(18-31)(19-25)(20-25)(21-49)(22-50)(23-36)(24-38)(25-38)(26-34)(26-41)(27-34)(27-39)(28-29)(28-36)(29-37)(30-31)(30-37)(31-36)(32-35)(32-42)(33-35)(33-40)(34-43)(35-44)(37-38)(39-45)(40-46)(41-42)(41-45)(42-46)(43-47)(43-49)(44-48)(44-50)(45-51)(46-51)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| T24 | 14 | — | 10.3390/ijms241511896 | 2023 |
| MCF-7 | 23 | — | 10.1016/j.jinorgbio.2020.11109... | 2020 |
| HeLa | 26 | — | 10.1016/j.jinorgbio.2020.11109... | 2020 |
| HEK293 | 89 | — | 10.1016/j.jinorgbio.2020.11109... | 2020 |
| MCF-10A | — | — | 10.3390/ijms241511896 | 2023 |
| Vero | — | — | 10.3390/ijms241511896 | 2023 |
| EA.hy926 | — | — | 10.3390/ijms241511896 | 2023 |
| HepG2 | — | — | 10.3390/ijms241511896 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«Fluorescence imaging and flow cytometry analysis demonstrate that 1 and 2 effectively penetrate the membrane and promote T24 cell death through the apoptotic pathway, mainly inducing early apoptosis o...»