Info
| ID | 2826 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "O": 1, "P": 1} |
| Abbreviation | 6b |
| SMILES | CCN(CC)C(=S)/N=C(\[O-])c1cccs1.Cc1ccc(C(C)C)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C38H42N2OPRuS2/(1-43)(2-48)(3-54)(4-49)(5-43)(6-53)(7-55)(8-61)(9-57)(10-56)(11-62)(12-59)(13-60)(14-47)(15-47)(16-47)(17-51)(18-58)(19-43)(20-71)(21-52)(22-78)(23-50)(24-45)(25-44)(26-64)(27-65)(28-63)(29-44)(30-66)(31-68)(32-44)(33-67)(34-45)(35-45)(36-72)(37-46)(38-72)(39-73)(40-46)(41-73)(42-46)(43-71)(44-71)(45-72)(46-73)(47-69)(48-49)(48-53)(49-54)(50-52)(50-78)(51-58)(51-69)(52-79)(53-75)(54-55)(55-75)(56-57)(56-61)(57-76)(58-70)(59-61)(59-62)(60-64)(60-65)(62-76)(63-64)(63-66)(65-77)(66-77)(67-68)(67-70)(68-69)(70-71)(72-81)(73-81)(74-79)(74-82)(74-83)(75-84)(76-84)(77-84)(78-86)(79-86)(80-81)(80-82)(80-85)(82-87)(84-87)(86-87)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.28 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| A549 | 0.59 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 1 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 4.1 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 4.3 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»