Info
| ID | 2825 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "O": 1, "P": 1} |
| Abbreviation | 5b |
| SMILES | CN(C)C(=S)/N=C(\[O-])c1cccs1.Cc1ccc(C(C)C)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H38N2OPRuS2/(1-42)(2-46)(3-43)(4-45)(5-47)(6-53)(7-49)(8-48)(9-54)(10-51)(11-52)(12-50)(13-44)(14-41)(15-41)(16-41)(17-65)(18-39)(19-39)(20-39)(21-62)(22-72)(23-60)(24-66)(25-40)(26-56)(27-57)(28-55)(29-40)(30-58)(31-61)(32-40)(33-59)(34-66)(35-66)(36-67)(37-67)(38-67)(39-65)(40-65)(41-63)(42-43)(42-45)(43-46)(44-50)(44-63)(45-69)(46-47)(47-69)(48-49)(48-53)(49-70)(50-64)(51-53)(51-54)(52-56)(52-57)(54-70)(55-56)(55-58)(57-71)(58-71)(59-61)(59-64)(60-62)(60-72)(61-63)(62-73)(64-65)(66-75)(67-75)(68-73)(68-76)(68-77)(69-78)(70-78)(71-78)(72-80)(73-80)(74-75)(74-76)(74-79)(76-81)(78-81)(80-81)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.34 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 1.1 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| A549 | 1.3 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 3.2 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 6.2 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»