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Complex #2824 — Ru(2) [4b]

2D Structure

Structure
⬇ MOL V3000

Info

ID2824
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 2, "O": 1, "P": 1}
Abbreviation4b
SMILESCCN(CC)C(=S)/N=C(\[O-])c1ccco1.Cc1ccc(C(C)C)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1

TUCAN

C38H42N2O2PRuS/(1-46)(2-48)(3-54)(4-49)(5-46)(6-53)(7-56)(8-62)(9-59)(10-60)(11-55)(12-57)(13-63)(14-43)(15-43)(16-43)(17-51)(18-58)(19-46)(20-71)(21-52)(22-74)(23-50)(24-44)(25-47)(26-64)(27-66)(28-61)(29-47)(30-65)(31-68)(32-47)(33-67)(34-44)(35-44)(36-72)(37-45)(38-72)(39-73)(40-45)(41-73)(42-45)(43-69)(44-72)(45-73)(46-71)(47-71)(48-49)(48-53)(49-54)(50-52)(50-74)(51-58)(51-69)(52-75)(53-77)(54-55)(55-77)(56-57)(56-62)(57-78)(58-70)(59-62)(59-63)(60-64)(60-65)(61-65)(61-66)(63-78)(64-79)(66-79)(67-68)(67-70)(68-69)(70-71)(72-81)(73-81)(74-84)(75-76)(75-84)(76-82)(76-83)(77-85)(78-85)(79-85)(80-81)(80-82)(80-86)(82-87)(84-87)(85-87)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
MDA-MB-2310.35 10.1021/acs.inorgchem.0c00319 2020
A5490.56 10.1021/acs.inorgchem.0c00319 2020
MRC-51.3 10.1021/acs.inorgchem.0c00319 2020
MCF-10A3.5 10.1021/acs.inorgchem.0c00319 2020
DU-1456.2 10.1021/acs.inorgchem.0c00319 2020

🧬 Cell Death Types (1)

Apoptosis high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»