Info
| ID | 2823 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "O": 1, "P": 1} |
| Abbreviation | 3b |
| SMILES | CN(C)C(=S)/N=C(\[O-])c1ccco1.Cc1ccc(C(C)C)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H38N2O2PRuS/(1-42)(2-46)(3-43)(4-45)(5-48)(6-54)(7-51)(8-52)(9-47)(10-49)(11-55)(12-50)(13-44)(14-39)(15-39)(16-39)(17-65)(18-40)(19-40)(20-40)(21-61)(22-68)(23-59)(24-66)(25-41)(26-56)(27-58)(28-53)(29-41)(30-57)(31-62)(32-41)(33-60)(34-66)(35-66)(36-67)(37-67)(38-67)(39-63)(40-65)(41-65)(42-43)(42-45)(43-46)(44-50)(44-63)(45-71)(46-47)(47-71)(48-49)(48-54)(49-72)(50-64)(51-54)(51-55)(52-56)(52-57)(53-57)(53-58)(55-72)(56-73)(58-73)(59-61)(59-68)(60-62)(60-64)(61-69)(62-63)(64-65)(66-75)(67-75)(68-78)(69-70)(69-78)(70-76)(70-77)(71-79)(72-79)(73-79)(74-75)(74-76)(74-80)(76-81)(78-81)(79-81)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.46 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| A549 | 1.4 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 1.9 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 6.2 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 7.4 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»