Info
| ID | 2822 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "O": 1, "P": 1} |
| Abbreviation | 2b |
| SMILES | CCN(CC)C(=S)/N=C(\[O-])c1ccccc1.Cc1ccc(C(C)C)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C40H44N2OPRuS/(1-48)(2-57)(3-60)(4-50)(5-48)(6-58)(7-59)(8-64)(9-66)(10-61)(11-67)(12-54)(13-48)(14-62)(15-45)(16-45)(17-45)(18-78)(19-78)(20-73)(21-69)(22-63)(23-77)(24-72)(25-52)(26-55)(27-51)(28-53)(29-49)(30-65)(31-70)(32-71)(33-49)(34-68)(35-49)(36-46)(37-56)(38-46)(39-46)(40-47)(41-79)(42-47)(43-79)(44-47)(45-75)(46-78)(47-79)(48-77)(49-77)(50-57)(50-81)(51-52)(51-55)(52-53)(53-56)(54-62)(54-75)(55-74)(56-74)(57-60)(58-60)(58-61)(59-63)(59-66)(61-81)(62-76)(63-82)(64-65)(64-66)(65-82)(67-69)(67-70)(68-69)(68-71)(70-83)(71-83)(72-73)(72-76)(73-75)(74-80)(76-77)(78-85)(79-85)(80-86)(80-87)(81-88)(82-88)(83-88)(84-85)(84-86)(84-89)(86-90)(88-90)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.39 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| A549 | 0.87 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 0.87 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 3.3 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 5.5 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»