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Complex #2822 — Ru(2) [2b]

2D Structure

Structure
⬇ MOL V3000

Info

ID2822
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 2, "O": 1, "P": 1}
Abbreviation2b
SMILESCCN(CC)C(=S)/N=C(\[O-])c1ccccc1.Cc1ccc(C(C)C)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1

TUCAN

C40H44N2OPRuS/(1-48)(2-57)(3-60)(4-50)(5-48)(6-58)(7-59)(8-64)(9-66)(10-61)(11-67)(12-54)(13-48)(14-62)(15-45)(16-45)(17-45)(18-78)(19-78)(20-73)(21-69)(22-63)(23-77)(24-72)(25-52)(26-55)(27-51)(28-53)(29-49)(30-65)(31-70)(32-71)(33-49)(34-68)(35-49)(36-46)(37-56)(38-46)(39-46)(40-47)(41-79)(42-47)(43-79)(44-47)(45-75)(46-78)(47-79)(48-77)(49-77)(50-57)(50-81)(51-52)(51-55)(52-53)(53-56)(54-62)(54-75)(55-74)(56-74)(57-60)(58-60)(58-61)(59-63)(59-66)(61-81)(62-76)(63-82)(64-65)(64-66)(65-82)(67-69)(67-70)(68-69)(68-71)(70-83)(71-83)(72-73)(72-76)(73-75)(74-80)(76-77)(78-85)(79-85)(80-86)(80-87)(81-88)(82-88)(83-88)(84-85)(84-86)(84-89)(86-90)(88-90)

Measurements (5)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
MDA-MB-2310.39 10.1021/acs.inorgchem.0c00319 2020
A5490.87 10.1021/acs.inorgchem.0c00319 2020
MRC-50.87 10.1021/acs.inorgchem.0c00319 2020
DU-1453.3 10.1021/acs.inorgchem.0c00319 2020
MCF-10A5.5 10.1021/acs.inorgchem.0c00319 2020

🧬 Cell Death Types (1)

Apoptosis high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»