Info
| ID | 2821 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "O": 1, "P": 1} |
| Abbreviation | 1b |
| SMILES | CN(C)C(=S)/N=C(\[O-])c1ccccc1.Cc1ccc(C(C)C)cc1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C38H40N2OPRuS/(1-48)(2-51)(3-44)(4-49)(5-50)(6-55)(7-57)(8-52)(9-58)(10-45)(11-42)(12-53)(13-65)(14-67)(15-41)(16-41)(17-41)(18-72)(19-71)(20-60)(21-54)(22-42)(23-42)(24-64)(25-46)(26-63)(27-66)(28-43)(29-56)(30-61)(31-62)(32-43)(33-59)(34-43)(35-47)(36-72)(37-72)(38-73)(39-73)(40-73)(41-68)(42-71)(43-71)(44-48)(44-75)(45-53)(45-68)(46-63)(46-69)(47-66)(47-69)(48-51)(49-51)(49-52)(50-54)(50-57)(52-75)(53-70)(54-76)(55-56)(55-57)(56-76)(58-60)(58-61)(59-60)(59-62)(61-77)(62-77)(63-64)(64-66)(65-67)(65-70)(67-68)(69-74)(70-71)(72-79)(73-79)(74-80)(74-81)(75-82)(76-82)(77-82)(78-79)(78-80)(78-83)(80-84)(82-84)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.61 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 1.8 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| A549 | 2.4 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 3.1 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 7.5 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»