Info
| ID | 2820 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | 6m |
| SMILES | CCN(CC)C(=S)NC(=O)c1cccs1.Cc1ccc(C(C)C)cc1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C38H43N2OPRuS2/(1-44)(2-49)(3-50)(4-62)(5-44)(6-55)(7-57)(8-56)(9-59)(10-58)(11-63)(12-60)(13-61)(14-48)(15-48)(16-52)(17-48)(18-53)(19-44)(20-72)(21-51)(22-54)(23-45)(24-46)(25-65)(26-66)(27-64)(28-46)(29-67)(30-68)(31-46)(32-69)(33-45)(34-45)(35-73)(36-47)(37-73)(38-74)(39-47)(40-74)(41-79)(42-47)(43-82)(44-72)(45-73)(46-72)(47-74)(48-71)(49-50)(49-55)(50-56)(51-54)(51-79)(52-53)(52-71)(53-70)(54-80)(55-76)(56-57)(57-76)(58-59)(58-62)(59-77)(60-62)(60-63)(61-65)(61-66)(63-77)(64-65)(64-67)(66-78)(67-78)(68-69)(68-71)(69-70)(70-72)(73-83)(74-83)(75-80)(75-82)(75-84)(76-85)(77-85)(78-85)(79-87)(80-87)(81-82)(81-83)(81-86)(85-88)(87-88)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.38 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| A549 | 0.51 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 1.2 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 2.9 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 6.6 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»