Info
| ID | 2819 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | 5m |
| SMILES | CN(C)C(=S)NC(=O)c1cccs1.Cc1ccc(C(C)C)cc1.[Cl-].c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C36H39N2OPRuS2/(1-43)(2-44)(3-54)(4-47)(5-49)(6-48)(7-51)(8-50)(9-55)(10-52)(11-53)(12-45)(13-42)(14-42)(15-42)(16-66)(17-46)(18-40)(19-40)(20-40)(21-61)(22-62)(23-67)(24-41)(25-57)(26-58)(27-56)(28-41)(29-59)(30-60)(31-41)(32-63)(33-67)(34-67)(35-68)(36-68)(37-73)(38-68)(39-76)(40-66)(41-66)(42-65)(43-44)(43-47)(44-48)(45-46)(45-65)(46-64)(47-70)(48-49)(49-70)(50-51)(50-54)(51-71)(52-54)(52-55)(53-57)(53-58)(55-71)(56-57)(56-59)(58-72)(59-72)(60-63)(60-65)(61-62)(61-73)(62-74)(63-64)(64-66)(67-77)(68-77)(69-74)(69-76)(69-78)(70-79)(71-79)(72-79)(73-81)(74-81)(75-76)(75-77)(75-80)(79-82)(81-82)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.67 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| A549 | 0.71 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MRC-5 | 1.2 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| DU-145 | 4.5 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
| MCF-10A | 6.7 | — | 10.1021/acs.inorgchem.0c00319 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«A marked increase in the apoptotic population was observed after treatment with the complexes in a dose-dependent manner.»